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Plasmon-Enabled High-Precision Single Molecule Localization Microscopy over an Extended Field of View
Muzzamal I. Shaukat, Carlos E. Rodriguez, M. Suhail Zubairy, Oumeng Zhang·June 30, 2026
physics.opticsQuantum Physics
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Abstract
We propose PIFLUX, a single-molecule localization scheme combining deep-subwavelength plasmonic illumination with widefield detection. Interference between counter-propagating gap plasmons and a normally incident optical field generates an illumination pattern whose position can be tuned through the plasmon phase while preserving its spatial period. A Cramér-Rao analysis shows PIFLUX reaches few-nanometer precision matching MINFLUX while doubling that of SIMFLUX over a micrometer field of view, and a maximum-likelihood estimator confirms this on a synthetic nuclear pore complex.